Crossroads Group Home for Girls

Crossroads Group Home programs facilitate emotional healing and growth, physical health, basic education, restorative independent living skills, social and recreational functioning and vocational pursuit. For those served who are emotionally handicapped, the emphasis is on the restorative and/or establishment of competence.

Endometriosis Association Support Group for the Upstate

is for women who have endometriosis and would like to come together to discuss tips on how to deal with endo.  Please email[email protected] for more information

Greenville Forward

is a non-political, non-profit organization which shepherds, champions, and facilitates achieving Greenville Vision 2025 goals and initiatives. The Vision focuses on sixteen areas such as the arts, government, transportation, healthcare, environment, education, and even coolness. For more information, embrace the vision and learn more at, or call Russell Stall at 233-8443.

South Carolina RSD Association

(Reflex Sympathetic Dystrophy), Greenville Chapter.

Down Syndrome Family Alliance of Greenville

welcomes you to join in honoring the lives and potential of adults and children with Down syndrome.

National Multiple Sclerosis Society

The mission of the National Multiple Sclerosis Society is to end the devastating effects of MS.

Sable Rescue, Inc.

 is located in Greenville South Carolina. The organization pulls animals under death sentence from animal control and shelters who do not have room for them any longer, and keeps the animals until a home can be found for them. Sable Rescue supports spay and neuter programs.

Red Ribbon Works

Red Ribbon Works is a parent-based community coalition, designed to get parents involved because they are the first line of defense in keeping kids off drugs. The coalition makes the community aware of the need to prevent and intervene on an ongoing basis.

Bethany Christian Services

Bethany is widely known as an adoption agency, but our Christian care extends to people struggling with unplanned pregnancies, infertility, and a multitude of other challenges. For more than sixty years, Bethany has responded with compassion, integrity, and commitment to the needs of children and families.

For nearly 40 years, The South Carolina Centers for Equal Justice, and its predecessors, through its offices in Anderson, Greenville and Spartanburg have been providing free civil legal assistance to the low income community in the Upstate. Call toll-free,
303 East River Street, Anderson
701 South Main Street, Greenville
148 East Main Street, Spartanburg

Southside Unity in the Community

Spartanburg, SC
Southside Unity in the Community is dedicated to promoting volunteerism within the Southside community. The program intends to make available in one central location resources, training and opportunities that will encourage volunteerism. Southside Unity in the Community strives to lead by example. Volunteerism is rarely taught in the Southside Community; it is our hope that this program managed entirely by volunteers will inspire volunteerism in present and future generations.


(Greenville Area Interfaith Hospitality Network) works to assist local congregations to share hospitality (in the form of emergency lodging and meals) with homeless families, and to help those families achieve self-sufficiency and self-fulfillment.

Habitat for Humanity of Greenville County

is a Christian housing ministry building simple, affordable homes for deserving, needy families. Habitat homeowners buy their homes at cost with a 20 year, interest free loan – and must perform 400 hours of “sweat equity” building their own home or other Habitat homes. We provide a “hand up” instead of a “hand out”.

SC Department of Social Services

Columbia, SC
This state agency offers servies and support for families and children.

Greer Community Ministries

serves and supports its elderly neighbors who are unable to prepare or secure food for themselves through our Mobile Meals program. The organization also provides a Senior Dining program and transportation as an outlet for those facing isolation and provides emergency food and clothing assistance for the disadvantaged within the Greater Greer area.

Alston Wilkes Society

provides support services to adult and juvenile offenders, former offenders and the homeless. Services include case management, employment assistance and referrals to other resources as needed. For more information, or the office closest to you, call our main office at  (803) 799-2490.

Connie Maxwell Children’s Home

provides hope for children and families dealing with difficult situations in their lives. This residential childcare ministry is headquartered in Greenwood, SC with four other campuses across the state

Greenville Literacy Association

The Greenville Literacy Association provides quality adult education in a flexible and comfortable environment. It is our goal to provide affordable and effective help for all people – no matter what your income or education level. Greenville Literacy Association’s mission is to enrich our community by increasing the literacy and employability of our citizens.

The Greenville Literacy Association is a not for profit, charitable organization formed under Section 501(c)3 of the U.S. Internal Revenue Code. Donations to the Greenville Literacy Association are tax-deductible as charitable contributions for US federal income tax purposes.

GLA promotes an inclusive and welcoming environment for all. We strive to be a community where people of different cultures, intellectual positions, and lifestyles can come to learn and give back to the community. GLA provides educational opportunities and support services on an individual basis including participants with disabilities such as learning, physical, emotional and mental. Through local partnerships, we do our best to provide wrap-around services to encourage stabilization, including referrals to partner agencies, based on students’ needs and goals.

SC Ovarian Cancer Foundation

This is an organization brought together by ovarian cancer patients, healthcare providers, and other concerned individuals for the dissemination of information about ovarian cancer. It has been designed for the patients, for support, for education of the public and healthcare providers, and for the furthering of research in ovarian cancer in the state of South Carolina. The Foundation has affiliations with major gynecologic oncology centers in this state.

Greenville Rape Crisis and Child Abuse Center

Greenville Rape Crisis and Child Abuse Center (GRCCAC) provides programs for the treatment, support and advocacy of child, teen and adult survivors of sexual assault, childhood sexual abuse and child abuse. Services include a 24/7 hotline, accompaniment to the ER for sexual assault victims, therapy, support groups, educational programs, parent education and support groups and more. Walk-ins welcome. 24/7 Hotline:  864-467-3633; Administrative offices:  864-331-0560.

American Leprosy Missions

is the oldest and largest U.S. organization devoted to restoring the lives of people affected by leprosy, is a non-denominational Christian non-profit organization. We support projects throughout Asia, Africa, and Latin America. Located in downtown Greenville, we need volunteers for switchboard relief, mailings, general clerical, and maintenance.

Operation Comfort

Fort Gordon, Augusta, GA
Operation Comfort is a special program in Army Community Service (ACS) that was established to support deployed service members and their families. Support through Operation Comfort may come in the form of respite childcare, outings or other events that boost morale, family members directly purchasing goods for service members and their families.

Hands On Greenville

Hands On Greenville was founded ten years ago in response to this challenge, with the goal of creating, organizing, and leading meaningful service projects that positively impact Greenville County. For additional information, visit Hands On Greenville.

Alzheimer’s Association – Upstate SC Chapter

The Alzheimer’s Association–Upstate South Carolina Chapter– is a non-profit charitable tax-exempt, voluntary health organization dedicated to family support, education, research, and advocacy. The National headquarter is located in Chicago. There are approximately 4.5 million persons affected by Alzheimer’s Disease or related dementia in the United States. It is estimated that 50,000 of those are in SC. Call  864-250-0029 in Greenville and  800-273-2555 in Anderson.

AID Upstate

For more information, call (864) 250-0607.

Generations Group Homes, Inc.

works with troubled boys ages 10-19. Call 874-243-5557.

Lutheran Family Services

offers adoption services, foster care, family counseling, and more. Call  864-848-3804.

Sterling Community Center

offers a variety of programs for youth, including after-school programs, intramural basketball, and special events.

Community Food Bank of the Piedmont

is an umbrella organization serving as a central distribution warehouse for hundreds of food pantries, emergency shelters, churches, food kitchens and other ministries across the Upstate. Through our network agencies, The Community Food Bank of the Piedmont is able to reach the nearly 175,000 hungry individuals living in the ten (10) counties we serve. Among this harsh figure, nearly 60,000 are children.

Iron Disorders Institute

Iron Disorders Institute exists so that people with iron disorders receive early, accurate diagnosis, appropriate treatment and are equipped to live in good health. Iron disorders are conditions of Iron-Out-of-Balance™ : iron deficiency anemia, anemia of inflammation, iron overload and iron overload with anemia. Abnormal iron levels can be fatal. Also visit

Piedmont Women’s Center

Free and confidential services include, but are not limited to: free pregnancy tests with immediate results and confidential counseling; a safe and secure place to talk about your feelings and explore all your alternatives; limited ultrasounds through your first trimester; referrals for medical and legal aid and information; and information and counceling about sexually transmitted diseases.

Goodwill Industries of Upper SC, Inc.

helps people with disabilities and special needs become fully independent citizens through training and employment leading to job placement. It provides rehabilitation service, training, work adjustment, employment opportunity, and placement in competitive industry for people with disabilities and special needs.

SC Center for Grassroots & Nonprofit Leadership

Clemson, SC
The Center seeks to actively build capacity and enhance resources of community and faith-based grassroots groups, nonprofit organizations, and individuals that are challenged to provide leadership and improve community life.

Safe Homes – Rape Crisis Coalition

Spartanburg, SC
Safe Home – Rape Crisis serves Spartanburg, Cherokee, and Union Counties, giving help, support, and emergency shelter to victims of rape and domestic violence and their children.

Rape Crisis Centers of South Carolina

gives help to victims of rape in South Carolina. Call  803-467-3633 for more information.

Daily Bread Ministries

This Greer, SC Soup Kitchen is a nonprofit, charitable organization operated solely by volunteers. The soup kitchen was created when concerned citizens in the Greer area saw the people in their town were going hungry.

Shepherd’s Gate

has earned a reputation in Northern California for rebuilding shattered lives. Since 1984, we have helped over 7,600 battered and homeless women and children. Call  864-268-4357 for more information.

Mental Health Association of Greenville – TEENline

Call  864-467-3344, TEENline: 864-467-TEEN (467-8336).

MEALS ON WHEELS of Greenville

MEALS ON WHEELS is a home-delivered hot meal service for persons who are unable to prepare their own food, primarily the frail elderly who are confined to their homes.

Safe Harbor, Inc.

helps with emergency shelter, counseling, case management, and other related services to victims of domestic violence and their children. The local hotline is  864-467-3636; the toll-free hotline number is  800-291-2139.

Commission for the Blind – South Carolina

The South Carolina Commission for the Blind is a state agency created to provide rehabilitation services, adjustment to blindness training, prevention of blindness, independent living services and various other services to blind and severely visually impaired citizens of South Carolina.

Shiphrah Ministries

is a maternity home for girls under 21 in Belton, SC. Call  864 338-4673 for more information.

Partners for a Heathy Community

works to improve the health and well-being of the people of Anderson, SC and the surrounding counties.

Battered Woman/Domestic Violence Hotline

Help is only a phone call away…

SC Association of Nonprofit Organizations

Columbia, SC
The mission of the S.C. Association of Nonprofit Organizations (SCANPO) is to serve, support and strengthen nonprofit organizations for a better South Carolina. SCANPO’s website features a search of all member nonprofit agencies, including social service organizations.


serves the entire nine-county area known as the Upstate and provides a safe place where GLBTQ youth meet and form friendships, build positive self esteem, and develop skills necessary for dealing with a negative environment.

Phyllis Wheatley Association

Started by Hattie Logan Duckett in 1919, the Phillis Wheatley Association was an organization that originally provided a social academic center for young African American women in Greenville, South Carolina. Today, 83 years later, the Phillis Wheatley Association caters to the needs of a diverse population throughout Greenville County and offers a wide range of services from serving meals to senior citizens to caring for preschoolers in a daycare program, from providing a Repertory Youth Theater for creative expression to hosting a nationally credentialed Big Brothers Big Sisters of America.


is a network of Parent Resource Centers located in Beaufort, Florence, Greenville, Lexington, and York Counties with the administrative office in Columbia. Some of the resources provided for parents by each center may be: home visitation to assist with effective parenting; pre-school kids clubs; pregnant and parenting teens groups; and fathers groups.

Birthright of Greenville

Birthright of Greenville is a confidential pregnancy resource center available to all women as long as they need us. We offer free pregnancy tests; a listening ear, support, and friendship; and maternity and baby items. We also offer information on adoption, prenatal care, and parenting skills in addition to referrals for medical, legal, counseling, and housing support. We are open Monday-Thursday, 9AM-3PM, and can be reached by phone at 864-281-7677.


Sunbelt Human Advancement Resources, Inc. (SHARE) is a Community Action Agency (CAA) serving Greenville, Anderson, Pickens and Oconee counties. We are a non-profit agency that provides a wide range of services to low and moderate-income residents in upstate South Carolina. The mission of SHARE is to help low-income individuals, families, and neighborhoods become self-sufficient.

Ronald McDonald House

is working to better the lives of children and their families around the world. The three core programs of RMHC – the Ronald McDonald House, Ronald McDonald Family Room and Ronald McDonald Care Mobile – are focused on helping families in need. Call  864-235-0506 for more information.

Calvary Home for Children

The mission of Calvary Home for Children in Anderson, SC is to present the hope of Christ to children who are without adequate family structure and in need of a long-term, Christ-centered home.

Carolina Pregnancy Center for Children

Offering compassionate support to women who are experiencing unplanned pregnancies. Confidential and personal counseling. Help with physical needs.

United Minsitries

United Minsitries is an extension of the servant ministry of local cooperating congregations. United Ministries assists poor people in emerging from hurting situations by providing for basic needs and by creating environments which allow people to make positive life changes.

Donate Blood

The nation’s blood banks, represented by the American Red Cross, American Association of Blood Banks, and America’s Blood Centers, are asking for immediate blood donations to boost already low blood supplies. Blood is traditionally in short supply due to the holidays, travel schedules, inclement weather, and illness.  Individuals are asked to support their local blood centers by making and keeping an appointment to donate immediately.

First Steps

South Carolina First Steps to school Readiness (‘First Steps’) is a comprehensive, results-oriented statewide education initiative to help prepare our children to reach first grade healthy and ready to succeed.

  • Anderson Count First Steps, call  864-222-0410.
  • Greenville County First Steps, call  864-467-3239.
  • Oconee County First Steps, call  864-882-3236.
  • Pickens County First Steps, call  864-654-3000.


American Red Cross – Upstate Chapter

Serving Greenville and Laurens counties. Call  864-271-8222 in Greenville and  864-938-6306 in Clinton.

American Cancer Society

864-591-0004,  864-989-8010,  800-237-6914

International Center of the Upstate

The International Center of the Upstate promotes cross culture understanding between international and local members of the Upstate. We offer language classes, social clubs, English conversation classes, as well as an active International Women’s Club. We can be contacted at [email protected].

Pendleton Place Children’s Shelter

The mission of the Shelter is to facilitate residential care programs in Greenville County, South Carolina, for children and youth, including, but not limited to, children who are abused, neglected or abandoned, who have run away from home, whose parents are injured or incarcerated, or who are otherwise without parental care

A Child’s Haven

offers programs designed to provide a rich, warm, loving, and supportive, family-like environment where your child may develop socially, emotionally, physically and intellectually.

Upstate Homeless Coalition

The Upstate Homeless Coalition of South Carolina is a private, non-profit organization. UHCSC is a collaborative organization dedicated to ending homelessness through programming, advocacy, and building safe and affordable housing.

United Minsitries

is an extension of the servant ministry of local cooperating congregations. United Ministries assists poor people in emerging from hurting situations by providing for basic needs and by creating environments which allow people to make positive life changes.

Open Arms Hospice

Open Arms Hospice, a ministry of Bon Secours St. Francis Health System, provides care, support, and nurturing for patients living with a life-limiting disease. When a cure is no longer possible and the patient has decided to stop aggressive treatment, our team of experts steps in to provide for the needs of the patient and family. Several volunteer opportunities are available. Please contact the volunteer coordinator at 864-688-1713.


CRISISline is a 24-hour, 7-day a week confidential hotline offering a nonjudgmental sounding board for people to talk about life’s struggles. Trained phone workers are available to offer a listening ear and to provide community resources and crisis intervention.

Killingsworth, Inc.

Columbia, SC
Killingsworth is a transitional home for women emerging from crisis situations. The home serves women from across the southeast, including 
Greenville, Anderson, Oconee, Pickens, and surrounding counties.

Miracle Hill Minsitries

exists that those most in need receive food, shelter, and compassion while hearing the gospel of Jesus Christ and becoming productive members of society. The motto is, “If you cannot find a friend in the world, you can find one here”.

Family Preservation & Child Welfare Network

The Mission of this web site is to improve the quality of life for families and children by advocating information sharing to create positive changes.

United Way of Greenville County

Since 1922, United Way of Greenville County has been a caring force in our community, working to identify our community’s most critical needs, then ensuring that programs are in place to impact those needs. United Way, its volunteers, and 46 community partner agencies, work together to get results by building a healthier, stronger community – changing lives throughout Greenville County for the better.